Prof. Ayşe NALBANTSOY's Lab
General Information
Development of vaccine adjuvant systems, in vitro/in vivo immunomodulatory effects of natural products and targeted activity screening tests, determination of the biological potential of snake and bee venoms and their biotechnological use.
Topics Studied
- Determination of the in vitro and in vivo biological activities (cytotoxicity, immunomodulatory effects, etc.) of natural compounds and molecules of plant and animal origin.
- Potential use of saponins in in vitro and in vivo adjuvant systems against bacterial, viral, and cancer vaccine antigens,
- Development of peptide-based breast cancer vaccine combinations with saponin adjuvants,
- Development of peptide-based breast cancer vaccine combinations with saponin adjuvants,
Selected Publications
B Kaya, Y Sarigiannis, A Nalbantsoy. Immunomodulatory Effects and Potential Therapeutic Application of Melittin in HER2-Expressing Breast Cancer Cells. International Journal of Peptide Research and Therapeutics 31 (6), 110 (2025)
D Özel, N Boke Sarikahya, A Tunçel, A Nalbantsoy, F Yurt. Preparation and biodistribution of [131I] iodoelmalienoside a, a saponin-based adjuvant, in mice. Journal of Radioanalytical and Nuclear Chemistry 334 (7), 4571-4582 (2025)
E Varol, AD Çağlar, FO Çöven, B Yücel, A Nalbantsoy. Cytotoxic and Apoptotic Potential of Different Ecotypes of Anatolian Honeybee (Apis Mellifera L.) Venoms on Various Cancer Cells. Journal of Apicultural Science 69 (2), 77-96 (2025)
KAMH Alsakini, FO Çöven, A Nalbantsoy. Adjuvant effects of novel water/oil emulsion formulations on immune responses against infectious bronchitis (IB) vaccine in mice. Biologicals 85, 101736 (2024)
M Damm, M Karış, D Petras, A Nalbantsoy, B Gocmen, RD Süssmuth. Venomics and Peptidomics of Palearctic Vipers: A Clade-Wide Analysis of Seven Taxa of the Genera Vipera, Montivipera, Macrovipera, and Daboia across Türkiye. Journal of proteome research 23 (8), 3524-3541 (2024)
O Oztunc, G Sumer Okkali, S Zeinali, A Nalbantsoy, N Boke Sarikahya. Four new triterpene saponins from Cephalaria speciosa and their potent cytotoxic and immunomodulatory activities. Scientific Reports 13 (1), 16964 (2023)
H Abaci, G Akagac, A Nalbantsoy, NB Sarikahya. A hederagenin-type triterpene saponin, sumbulianoside a from Cephalaria sumbuliana and its potent immunomodulatory activity against seasonal flu virus H3N2. Natural Product Rresearch 36 (10), 2495-2503 (2022)
Nalbantsoy A, Karış M., Yalçın H. T. & Göçmen B. Biological activities of skin and parotoid gland secretions of bufonid toads (Bufo bufo, Bufo verrucosissimus and Bufotes variabilis) from Turkey. Biomedicine & Pharmacotherapy, 80: 298-303, (2016).
