Biomimetic Microsystems Laboratory

Area of Expertise

• Biomimetic microsystems; organ-on-chips, disease modeling, microfluidic systems, organoids
• Design of drug delivery systems; microfluidic synthesis of nanoparticles for passie and active targetting 
• Life science applications of supercritical fluids; decellularization of tissues, scaffolds, sterilization

Keywords: Organ-on-chips; Microfluidics; Supercritical fluids; Biomaterials; Hydrogels

Projects

3D biomimetic breast cancer invasion model for testing new therapies. Funded by TUBITAK (120N422), bilateral collaboration with NCBR, Poland, PI, (2021-2024)

Development of in vitro three-dimensional cerebral organoid culture based Rett syndrome-on-a-chip model. Funded by TUBITAK (119M578), PI, (2019-2022)

Microfluidic platforms for drug delivery applications: characterization and continuous production of monodispersed lipidic drug nano-self-assemblies, Danish Agency for Science and Higher Education, PI of Turkish partner, (2019-2021) (Bilateral project with University of Copenhagen, Denmark)

Development of innovative biomedical devices with a translational medicine approach in pulmonary diseases, Ministry of Development, 21531, Researcher, 2019-2022

In vitro 3D model development for the assessment of immune response towards implantable biomaterials in cartilage defects. Funded by TUBITAK (219M057), PI, (2020-2021)

Publications

Burcu Yaldiz, Pelin Saglam-Metiner, Sefa Burak Cam, Petek Korkusuz, Ozlem Yesil-Celiktas (2021) Effect of sterilization methods on the mechanical stability and extracellular matrix constituents of decellularized brain tissue. Journal of Supercritical Fluids, 175, 105299.

Ecem Saygili, Ece Yildiz-Ozturk, Macauley J. Green, Amir M. Ghaemmaghami, Ozlem Yesil-Celiktas (2021) Human Lung-on-chips: Advanced systems for respiratory virus models and assessment of immune response. Biomicrofluidics, 15, 021501. 

Ecem Saygili, Asli Aybike Dogan, Mohamed Shehata Draz, Ozlem Yesil-Celiktas (2020) 3D Bioprinting: A Powerful Tool to Leverage Tissue Engineering and Microbial Systems. Bioprinting, 18, Article e00071

Fatemeh Sharifi, Su Su Htwe, Martina Righi, Hua Liu, Anna Peietralunga, Ozlem Yesil-Celiktas, Sushila Maharjan, Byung-Hyun Cha, Su-Ryon Shin, Mehmet Remzi Dokmeci, Nihal Engin Vrana, Amir Ghaemmaghammi, Ali Khademhosseini, Yu Shrike Zhang (2019) A foreign body response-on-a-chip platform. Advanced Healthcare Materials, 8, 1801425.

Ozlem Yesil-Celiktas, Shabir Hassan, Amir K. Miri, Sushila Maharjan, Rawan Al-kharboosh, Alfredo Quiñones-Hinojosa, Yu Shrike Zhang (2018) Mimicking human pathophysiology in organ-on-chip devices. Advanced Biosystems, 2 (10) 1800109