Green Bioprocesses and Bioproduction Engineering Laboratory
Prof. Suphi S. ONCEL's LAB
Dr. Ilgın KIMIZ GEBOLOĞLU
Dr. Çağla YARKENT
General Information
The Green Bioprocesses and Bioproduction Engineering Laboratory is a multi-disciplinary research group dedicated to developing sustainable, innovative, and scalable biotechnological production systems. Our laboratory integrates environmentally friendly bioprocess design with the production of high-value-added biological products, delivering innovative solutions in the fields of energy and health. By combining fundamental scientific research with engineering approaches, we conduct process development and optimization studies ranging from laboratory scale to pilot scale.
Research Areas
· Microalgal Bioprocesses and Green Energy Engineering: Sustainable microalgae-based production systems, biofuel and high-value biomolecule production, photobioreactor design, and process optimization.
· Sustainable and Green Process Design: Design and integration of energy-efficient, environmentally responsible, and industrially applicable bioproduction processes.
· Cell Culture-Based Bioprocesses: Production of vaccines, recombinant proteins, and monoclonal antibodies in mammalian cell lines, culture medium optimization, and scale-up studies.
· Innovative Delivery Systems and Biomaterial Production: Development of nanoparticle-based delivery systems, controlled-release platforms, and functional biomaterials for therapeutic applications.
Alongside academic research, our laboratory actively develops national and international projects and collaborates with industry to enhance the impact of biotechnology on sustainable development with a bioengineering perspective.
Selected Publications
· Yarkent, Ç., Mutaf-Kılıc, T., & Oncel, S. S. (2026). Prospects of Microalgae Industry 5.0: Customization and New Advanced Technology for Microalgae Pigments Production. In Pigments from Microalgae Handbook–Volume II: Bioprocess Engineering, Smart Extraction Technologies, Omics Tools, and Sustainability-Driven Innovations (pp. 365-391). Cham: Springer Nature Switzerland.
· Erdoğan, B., Demi̇rden, S. F., Oncel, D. S., & Oncel, S. S. (2026). A novel multi-directional modular mixing system for bringing new insight to microalgae production in panel photobioreactors. Biochemical Engineering Journal, 110074.
· Kurt, S., Kimiz-Gebologlu, I., Cinar, O., & Oncel, S. S. (2026). Natural nanocarriers in oncology: The targeting and delivery capabilities of extracellular vesicles. OpenNano, 28, 100287.
· Cinar, O., Kimiz-Gebologlu, I., & Oncel, S. S. (2025). Nanoparticle-Based Therapeutic Strategies in Respiratory Diseases: Current Approaches and Future Perspectives. Thoracic Research and Practice, 26(Suppl 1), 31.
· Yarkent, Ç., Öncel, D. Ş., & Oncel, S. S. (2025). Exploring the Effect of Production Conditions of Chlorella minutissima on Its Pharmaceutical Potential: A Natural Source for Bioactive Compounds. Asia‐Pacific Journal of Chemical Engineering, e70156.
· Tuğcu, B., Yarkent, Ç., Çelik, Y., Köse, A., & Oncel, S. S. (2025). Comparison of HepG2 Cell Spheroid Formation Under Bioreactor Productions with Two Mixing Strategies by RCCS and CSTR. Microgravity Science and Technology, 37(2), 16.
· Yarkent, Ç., Oral, İ., Öncel, D. Ş., & Oncel, S. S. (2024). Focusing on a new biohydrogen production strategy (HS-HS) using Chlamydomonas reinhardtii mutants: The effects of mutation points on biohydrogen production capacity. International Journal of Hydrogen Energy, 52, 88-102.
· Demirden, S. F., Kimiz-Gebologlu, I., & Oncel, S. S. (2024). Animal cell lines as expression platforms in viral vaccine production: A post COVID-19 perspective. ACS omega, 9(15), 16904-16926.
· Kimiz-Gebologlu, I., & Oncel, S. S. (2022). Exosomes: large-scale production, isolation, drug loading efficiency, and biodistribution and uptake. Journal of Controlled Release, 347, 533-543.
· Gürlek, C., Yarkent, Ç., Köse, A., Tuğcu, B., Geboloğlu, I. K., Öncel, S. Ş., & Elibol, M. (2020). Screening of antioxidant and cytotoxic activities of several microalgal extracts with pharmaceutical potential. Health and Technology, 10(1), 111-117.
